Assay Detail
Binding
CHEMBL829587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of yeast glutathione reductase over 30 minutes pH 7.4 at 25 degree C
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutathione reductase (CHEMBL4119) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino)- phenylcarbamoylsulfanyl]propionic acid and its derivatives as a novel class of glutathione reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.07 | 4.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190205 | — | — | 1 | 4.07 |
| CHEMBL189994 | — | — | 1 | - |
| CHEMBL190827 | — | — | 1 | - |
| CHEMBL189153 | — | — | 1 | - |
| CHEMBL191549 | — | — | 1 | - |
| CHEMBL361887 | — | — | 1 | - |
| CHEMBL513 | CARMUSTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190205 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL189994 | — | IC50 | = | 117000.0 | nM | - |
| CHEMBL190827 | — | IC50 | = | 149000.0 | nM | - |
| CHEMBL189153 | — | IC50 | = | 455000.0 | nM | - |
| CHEMBL191549 | — | IC50 | = | 515000.0 | nM | - |
| CHEMBL361887 | — | IC50 | = | 477000.0 | nM | - |
| CHEMBL513 | CARMUSTINE | IC50 | = | 441000.0 | nM | - |