Assay Detail
Binding
CHEMBL829603
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for D1-like [3H]-SCH- 23390 receptor was determined using caudate-putamen of adult male Spragueo?=Dawley rats
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Caudate-putamen |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.74 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426425 | — | — | 1 | 6.59 |
| CHEMBL181203 | — | — | 1 | 6.45 |
| CHEMBL25236 | BP-897 | — | 1 | 6.20 |
| CHEMBL179757 | — | — | 1 | 6.10 |
| CHEMBL341774 | — | — | 1 | 6.04 |
| CHEMBL179805 | — | — | 1 | 5.91 |
| CHEMBL179376 | — | — | 1 | 5.61 |
| CHEMBL359654 | — | — | 1 | 5.34 |
| CHEMBL179781 | — | — | 1 | 5.24 |
| CHEMBL362665 | — | — | 1 | 5.22 |
| CHEMBL413554 | — | — | 1 | 5.10 |
| CHEMBL345106 | — | — | 1 | 5.05 |
| CHEMBL368686 | — | — | 1 | - |
| CHEMBL180107 | — | — | 1 | - |
| CHEMBL361756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426425 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL181203 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL25236 | BP-897 | Ki | = | 636.0 | nM | 6.20 |
| CHEMBL179757 | — | Ki | = | 791.0 | nM | 6.10 |
| CHEMBL341774 | — | Ki | = | 904.0 | nM | 6.04 |
| CHEMBL179805 | — | Ki | = | 1218.0 | nM | 5.91 |
| CHEMBL179376 | — | Ki | = | 2467.0 | nM | 5.61 |
| CHEMBL359654 | — | Ki | = | 4602.0 | nM | 5.34 |
| CHEMBL179781 | — | Ki | = | 5802.0 | nM | 5.24 |
| CHEMBL362665 | — | Ki | = | 6051.0 | nM | 5.22 |
| CHEMBL413554 | — | Ki | = | 7947.0 | nM | 5.10 |
| CHEMBL345106 | — | Ki | = | 8893.0 | nM | 5.05 |
| CHEMBL368686 | — | Ki | > | 100.0 | nM | - |
| CHEMBL180107 | — | Ki | = | 152567.0 | nM | - |
| CHEMBL361756 | — | Ki | > | 250000.0 | nM | - |