Assay Detail
Binding
CHEMBL829620
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Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.92 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370038 | — | — | 1 | 8.41 |
| CHEMBL276815 | (S)-AMPA | — | 1 | 7.78 |
| CHEMBL370941 | — | — | 1 | 7.10 |
| CHEMBL372643 | — | — | 1 | 5.79 |
| CHEMBL193087 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370038 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL276815 | (S)-AMPA | Ki | = | 16.8 | nM | 7.78 |
| CHEMBL370941 | — | Ki | = | 80.2 | nM | 7.10 |
| CHEMBL372643 | — | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL193087 | — | Ki | = | 2930.0 | nM | 5.53 |