Assay Detail
Binding
CHEMBL829638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]U-69593 binding to delta and kappa opioid receptors expressed in HEK 293 cells with 100 nM benzylidenenaltrexone
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Opioid receptors; delta & kappa (CHEMBL2095151) ↗| Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
Publication
A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.75 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611143 | — | — | 1 | 8.94 |
| CHEMBL611406 | — | — | 1 | 8.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611143 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL611406 | — | Ki | = | 2.75 | nM | 8.56 |