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Assay Detail

CHEMBL829666

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Binding
Binding affinity for rat brain opioid receptor delta 1
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).
Fujita Y, Tsuda Y, Motoyama T, Li T, Miyazaki A, Yokoi T, Sasaki Y, Ambo A, Niizuma H, Jinsmaa Y, Bryant SD, Lazarus LH, Okada Y.
Bioorg Med Chem Lett (2005) 15 : 599 -602
PubMed 15664820 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 6.30 10.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL571492 1 10.66
CHEMBL182021 1 7.28
CHEMBL183609 1 6.92
CHEMBL413050 1 6.78
CHEMBL424797 1 6.76
CHEMBL183497 1 6.71
CHEMBL183302 1 6.68
CHEMBL70 MORPHINE 4.0 1 6.66
CHEMBL180037 1 6.48
CHEMBL368443 1 6.34
CHEMBL361157 1 6.34
CHEMBL182538 1 6.31
CHEMBL182898 1 6.28
CHEMBL183250 1 6.19
CHEMBL180548 1 5.94
CHEMBL183602 1 5.84
CHEMBL180171 1 5.83
CHEMBL440019 1 5.62
CHEMBL181360 1 5.44
CHEMBL180294 1 5.34
CHEMBL360892 1 5.04
CHEMBL362054 1 5.02
CHEMBL180386 1 4.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL571492 Ki = 0.022 nM 10.66
CHEMBL182021 Ki = 52.8 nM 7.28
CHEMBL183609 Ki = 120.0 nM 6.92
CHEMBL413050 Ki = 166.0 nM 6.78
CHEMBL424797 Ki = 175.0 nM 6.76
CHEMBL183497 Ki = 197.0 nM 6.71
CHEMBL183302 Ki = 208.0 nM 6.68
CHEMBL70 MORPHINE Ki = 217.0 nM 6.66
CHEMBL180037 Ki = 328.0 nM 6.48
CHEMBL368443 Ki = 460.0 nM 6.34
CHEMBL361157 Ki = 455.0 nM 6.34
CHEMBL182538 Ki = 492.0 nM 6.31
CHEMBL182898 Ki = 531.0 nM 6.28
CHEMBL183250 Ki = 649.0 nM 6.19
CHEMBL180548 Ki = 1150.0 nM 5.94
CHEMBL183602 Ki = 1450.0 nM 5.84
CHEMBL180171 Ki = 1470.0 nM 5.83
CHEMBL440019 Ki = 2410.0 nM 5.62
CHEMBL181360 Ki = 3650.0 nM 5.44
CHEMBL180294 Ki = 4580.0 nM 5.34
CHEMBL360892 Ki = 9230.0 nM 5.04
CHEMBL362054 Ki = 9490.0 nM 5.02
CHEMBL180386 Ki = 46500.0 nM 4.33