Assay Detail
Binding
CHEMBL829679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.52 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329566 | — | — | 1 | 9.37 |
| CHEMBL193639 | — | — | 2 | 9.28 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.96 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.92 |
| CHEMBL363581 | — | — | 1 | 8.92 |
| CHEMBL366164 | — | — | 1 | 8.85 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 8.80 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 8.77 |
| CHEMBL435301 | — | — | 1 | 8.37 |
| CHEMBL194659 | — | — | 1 | 8.12 |
| CHEMBL364270 | — | — | 1 | 7.85 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.48 |
| CHEMBL195706 | — | — | 1 | 7.48 |
| CHEMBL193435 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329566 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL193639 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL193639 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL42 | CLOZAPINE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL715 | OLANZAPINE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL363581 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL366164 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL654 | MIRTAZAPINE | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL6437 | MIANSERIN | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL435301 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL194659 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL364270 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL85 | RISPERIDONE | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL195706 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL193435 | — | Ki | = | 42.0 | nM | 7.38 |