Assay Detail
Binding
CHEMBL829693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 6.21 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368442 | — | — | 1 | 7.38 |
| CHEMBL180693 | — | — | 1 | 7.30 |
| CHEMBL180236 | — | — | 1 | 7.04 |
| CHEMBL361826 | — | — | 1 | 6.90 |
| CHEMBL181925 | — | — | 1 | 6.68 |
| CHEMBL178172 | — | — | 1 | 6.67 |
| CHEMBL362268 | — | — | 1 | 6.66 |
| CHEMBL183915 | — | — | 1 | 6.60 |
| CHEMBL178662 | — | — | 1 | 6.59 |
| CHEMBL183183 | — | — | 1 | 6.49 |
| CHEMBL181873 | — | — | 1 | 6.36 |
| CHEMBL360280 | — | — | 1 | 6.31 |
| CHEMBL180559 | — | — | 1 | 6.28 |
| CHEMBL181005 | — | — | 1 | 6.25 |
| CHEMBL181346 | — | — | 1 | 6.19 |
| CHEMBL367351 | — | — | 1 | 6.16 |
| CHEMBL181067 | — | — | 1 | 6.03 |
| CHEMBL360366 | — | — | 1 | 6.00 |
| CHEMBL181400 | — | — | 1 | 5.95 |
| CHEMBL181468 | — | — | 1 | 5.84 |
| CHEMBL263494 | — | — | 1 | 5.78 |
| CHEMBL179932 | — | — | 1 | 5.74 |
| CHEMBL180588 | — | — | 1 | 5.68 |
| CHEMBL182259 | — | — | 1 | 5.56 |
| CHEMBL181062 | — | — | 1 | 5.44 |
| CHEMBL434334 | — | — | 1 | 5.34 |
| CHEMBL180832 | — | — | 1 | 5.29 |
| CHEMBL179935 | — | — | 1 | 5.23 |
| CHEMBL180811 | — | — | 1 | - |
| CHEMBL362374 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368442 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL180693 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL180236 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL361826 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL181925 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL178172 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL362268 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL183915 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL178662 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL183183 | — | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL181873 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL360280 | — | Ki | = | 485.0 | nM | 6.31 |
| CHEMBL180559 | — | Ki | = | 526.0 | nM | 6.28 |
| CHEMBL181005 | — | Ki | = | 557.0 | nM | 6.25 |
| CHEMBL181346 | — | Ki | = | 645.0 | nM | 6.19 |
| CHEMBL367351 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL181067 | — | Ki | = | 945.0 | nM | 6.03 |
| CHEMBL360366 | — | Ki | = | 1010.0 | nM | 6.00 |
| CHEMBL181400 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL181468 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL263494 | — | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL179932 | — | Ki | = | 1830.0 | nM | 5.74 |
| CHEMBL180588 | — | Ki | = | 2080.0 | nM | 5.68 |
| CHEMBL182259 | — | Ki | = | 2780.0 | nM | 5.56 |
| CHEMBL181062 | — | Ki | = | 3660.0 | nM | 5.44 |
| CHEMBL434334 | — | Ki | = | 4520.0 | nM | 5.34 |
| CHEMBL180832 | — | Ki | = | 5170.0 | nM | 5.29 |
| CHEMBL179935 | — | Ki | = | 5830.0 | nM | 5.23 |
| CHEMBL180811 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL362374 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL181630 | — | Ki | > | 6666.0 | nM | - |