Assay Detail
Functional
CHEMBL829720
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Effective concentration against heat shock protein HSP90-alpha in SKBr3 cells
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SKBr3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.27 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365159 | — | — | 1 | 7.70 |
| CHEMBL191635 | — | — | 1 | 7.52 |
| CHEMBL193282 | — | — | 1 | 7.05 |
| CHEMBL192145 | — | — | 1 | 6.89 |
| CHEMBL273986 | — | — | 1 | 6.80 |
| CHEMBL112953 | — | — | 1 | 6.77 |
| CHEMBL192062 | — | — | 1 | 6.51 |
| CHEMBL192647 | — | — | 1 | 6.48 |
| CHEMBL191786 | — | — | 1 | 6.33 |
| CHEMBL349231 | — | — | 1 | 5.80 |
| CHEMBL193259 | — | — | 1 | 5.70 |
| CHEMBL161992 | — | — | 1 | 5.44 |
| CHEMBL352683 | — | — | 2 | 5.44 |
| CHEMBL190518 | — | — | 1 | 5.38 |
| CHEMBL191668 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365159 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL191635 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL193282 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL192145 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL273986 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL112953 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL192062 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL192647 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL191786 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL349231 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL193259 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL161992 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL352683 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL190518 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL352683 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL191668 | — | EC50 | = | 5300.0 | nM | 5.28 |