Assay Detail
Binding
CHEMBL829787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Target
GABA A receptor alpha-5/beta-3/gamma-2 (CHEMBL2111374) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.87 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191088 | — | — | 1 | 8.12 |
| CHEMBL372281 | — | — | 1 | 7.99 |
| CHEMBL192554 | — | — | 1 | 7.76 |
| CHEMBL192555 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191088 | — | Ki | = | 7.57 | nM | 8.12 |
| CHEMBL372281 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL192554 | — | Ki | = | 17.2 | nM | 7.76 |
| CHEMBL192555 | — | Ki | = | 24.1 | nM | 7.62 |