Assay Detail
Binding
CHEMBL829822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant against catalytic domain of human carbonic anhydrase IX
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.25 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 8.29 |
| CHEMBL6685 | — | — | 1 | 7.85 |
| CHEMBL6633 | — | — | 1 | 7.80 |
| CHEMBL6919 | — | — | 1 | 7.68 |
| CHEMBL6784 | — | — | 1 | 7.66 |
| CHEMBL7146 | — | — | 1 | 7.62 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 7.58 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL6753 | — | — | 1 | 7.52 |
| CHEMBL6705 | — | — | 1 | 7.48 |
| CHEMBL7087 | — | — | 1 | 7.48 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.43 |
| CHEMBL268439 | — | — | 1 | 7.42 |
| CHEMBL266240 | — | — | 1 | 7.41 |
| CHEMBL265674 | — | — | 1 | 7.39 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.33 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.28 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.99 |
| CHEMBL6852 | — | — | 1 | 6.62 |
| CHEMBL6853 | — | — | 1 | 6.61 |
| CHEMBL7092 | — | — | 1 | 6.58 |
| CHEMBL6724 | — | — | 1 | 6.57 |
| CHEMBL268177 | — | — | 1 | 6.54 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.53 |
| CHEMBL7204 | — | — | 1 | 6.52 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL750 | ZONISAMIDE | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL6685 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL6633 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL6919 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL6784 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL7146 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL414 | CARZENIDE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL6753 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL6705 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL7087 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL268439 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL266240 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL265674 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL419 | MAFENIDE | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL6852 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL6853 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL7092 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL6724 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL268177 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 294.0 | nM | 6.53 |
| CHEMBL7204 | — | Ki | = | 305.0 | nM | 6.52 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 1590.0 | nM | 5.80 |