Assay Detail
Functional
CHEMBL829929
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [1-beta-3H]-androstenedione binding to human steroid 5-alpha-reductase type I expressed in DU-145 cells at 10 uM
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.67 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 7.22 |
| CHEMBL77789 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL710 | FINASTERIDE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL77789 | — | IC50 | = | 770.0 | nM | 6.11 |