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Assay Detail

CHEMBL829933

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration for rat liver Monoamine oxidase A using 5-hydroxytryptamine
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Amine oxidase [flavin-containing] A (CHEMBL3358)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases.
Bertini V, Buffoni F, Ignesti G, Picci N, Trombino S, Iemma F, Alfei S, Pocci M, Lucchesini F, De Munno A.
J Med Chem (2005) 48 : 664 -670
PubMed 15689151 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.40 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL537406 1 5.00
CHEMBL534467 1 4.36
CHEMBL537623 1 4.20
CHEMBL541126 1 4.02
CHEMBL537624 1 -
CHEMBL537175 1 -
CHEMBL537174 1 -
CHEMBL537402 1 -
CHEMBL557160 1 -
CHEMBL537628 1 -
CHEMBL534914 1 -
CHEMBL537401 1 -
CHEMBL536719 1 -
CHEMBL536951 1 -
CHEMBL537845 1 -
CHEMBL536953 1 -
CHEMBL559376 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL537406 IC50 = 10000.0 nM 5.00
CHEMBL534467 IC50 = 44000.0 nM 4.36
CHEMBL537623 IC50 = 63000.0 nM 4.20
CHEMBL541126 IC50 = 95000.0 nM 4.02
CHEMBL537624 IC50 = 300000.0 nM -
CHEMBL537175 IC50 = 2200000.0 nM -
CHEMBL537174 IC50 > 100000.0 nM -
CHEMBL537402 IC50 > 100000.0 nM -
CHEMBL557160 IC50 > 100000.0 nM -
CHEMBL537628 IC50 = 150000.0 nM -
CHEMBL534914 IC50 = 420000.0 nM -
CHEMBL537401 IC50 > 1600000.0 nM -
CHEMBL536719 IC50 > 1600000.0 nM -
CHEMBL536951 IC50 = 630000.0 nM -
CHEMBL537845 IC50 = 170000.0 nM -
CHEMBL536953 IC50 > 2000000.0 nM -
CHEMBL559376 IC50 > 100000.0 nM -