Assay Detail
Binding
CHEMBL829974
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Binding constant measured against Alpha-1A adrenergic receptor in human prostate; +:inactive
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Prostate gland |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacophore identification of alpha(1A)-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.26 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56438 | — | — | 1 | 6.89 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.60 |
| CHEMBL98241 | — | — | 1 | 6.54 |
| CHEMBL19476 | L-765314 | — | 1 | 6.38 |
| CHEMBL179440 | — | — | 1 | 6.37 |
| CHEMBL362863 | — | — | 1 | 6.31 |
| CHEMBL320397 | — | — | 1 | 6.20 |
| CHEMBL181583 | — | — | 1 | 5.60 |
| CHEMBL123138 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56438 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL13647 | BMY-7378 | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL98241 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL19476 | L-765314 | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL179440 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL362863 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL320397 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL181583 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL123138 | — | Ki | = | 3300.0 | nM | 5.48 |