Assay Detail
Binding
CHEMBL829977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [18F]PET binding to dopamine transporter of human brain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365649 | — | — | 1 | 8.30 |
| CHEMBL184807 | — | — | 1 | 8.30 |
| CHEMBL185608 | — | — | 1 | 8.30 |
| CHEMBL186119 | — | — | 1 | 8.30 |
| CHEMBL186306 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365649 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL184807 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL185608 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL186119 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL186306 | — | Ki | = | 5.0 | nM | 8.30 |