Assay Detail
Binding
CHEMBL829978
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Inhibitory binding affinity for phenylethanolamine N-methyl-transferase (PNMT)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL4617) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.45 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 8.51 |
| CHEMBL337144 | — | — | 1 | 8.31 |
| CHEMBL38681 | — | — | 1 | 8.00 |
| CHEMBL275595 | — | — | 1 | 7.16 |
| CHEMBL39493 | — | — | 1 | 7.05 |
| CHEMBL290890 | — | — | 1 | 6.57 |
| CHEMBL26717 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL337144 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL38681 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL275595 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL39493 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL290890 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL26717 | — | Ki | = | 280.0 | nM | 6.55 |