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Assay Detail

CHEMBL829993

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Effective concentration against neuraminidase Influenza A virus A/N2/Tokyo strain
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza A virus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Neuraminidase (CHEMBL2051)
Type SINGLE PROTEIN
Organism Influenza A virus (A/Puerto Rico/8/1934(H1N1))

Publication

Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.
Maring CJ, Stoll VS, Zhao C, Sun M, Krueger AC, Stewart KD, Madigan DL, Kati WM, Xu Y, Carrick RJ, Montgomery DA, Kempf-Grote A, Marsh KC, Molla A, Steffy KR, Sham HL, Laver WG, Gu YG, Kempf DJ, Kohlbrenner WE.
J Med Chem (2005) 48 : 3980 -3990
PubMed 15943472 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 5.49 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL362993 1 6.30
CHEMBL370047 1 6.10
CHEMBL195156 1 6.10
CHEMBL424821 1 5.82
CHEMBL191512 1 5.72
CHEMBL382322 1 5.62
CHEMBL426810 1 5.50
CHEMBL373336 1 5.43
CHEMBL369125 1 5.30
CHEMBL195871 1 5.28
CHEMBL366026 1 5.07
CHEMBL365976 1 5.03
CHEMBL190819 1 5.03
CHEMBL195288 1 4.58
CHEMBL192279 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL362993 EC50 = 500.0 nM 6.30
CHEMBL370047 EC50 = 800.0 nM 6.10
CHEMBL195156 EC50 = 800.0 nM 6.10
CHEMBL424821 EC50 = 1500.0 nM 5.82
CHEMBL191512 EC50 = 1900.0 nM 5.72
CHEMBL382322 EC50 = 2400.0 nM 5.62
CHEMBL426810 EC50 = 3200.0 nM 5.50
CHEMBL373336 EC50 = 3700.0 nM 5.43
CHEMBL369125 EC50 = 5000.0 nM 5.30
CHEMBL195871 EC50 = 5300.0 nM 5.28
CHEMBL366026 EC50 = 8500.0 nM 5.07
CHEMBL365976 EC50 = 9260.0 nM 5.03
CHEMBL190819 EC50 = 9260.0 nM 5.03
CHEMBL195288 EC50 = 26400.0 nM 4.58
CHEMBL192279 EC50 > 100000.0 nM -