Assay Detail
Binding
CHEMBL829994
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Effective concentration against neuraminidase of Influenza B virus B/Memphis strain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza B virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL3377) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza B virus (strain B/Lee/1940) |
Publication
Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.98 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373336 | — | — | 1 | 5.22 |
| CHEMBL191512 | — | — | 1 | 5.22 |
| CHEMBL382322 | — | — | 1 | 5.05 |
| CHEMBL195871 | — | — | 1 | 4.96 |
| CHEMBL426810 | — | — | 1 | 4.96 |
| CHEMBL369125 | — | — | 1 | 4.82 |
| CHEMBL366026 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373336 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL191512 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL382322 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL195871 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL426810 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL369125 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL366026 | — | EC50 | = | 23000.0 | nM | 4.64 |