Assay Detail
Binding
CHEMBL829997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against rat alpha-7 nicotinic acetylcholine receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.76 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.89 |
| CHEMBL21553 | — | — | 1 | 4.70 |
| CHEMBL282473 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL21553 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL282473 | — | EC50 | = | 21000.0 | nM | 4.68 |