Assay Detail
Binding
CHEMBL830018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against human ALR1 Aldehyde reductase using DL-glyceraldehyde
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member A1 (CHEMBL2246) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.60 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | 2.0 | 1 | 5.92 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL266497 | SORBINIL | IC50 | = | 5400.0 | nM | 5.27 |