Assay Detail
Binding
CHEMBL830027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against Nicotinic acetylcholine receptor alpha4-beta2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907589) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.50 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111659 | ALTINICLINE | 2.0 | 1 | 6.50 |
| CHEMBL606669 | — | — | 1 | 6.50 |
| CHEMBL187927 | DIANICLINE | 3.0 | 1 | - |
| CHEMBL134713 | GTS-21 | 2.0 | 1 | - |
| CHEMBL189861 | — | — | 1 | - |
| CHEMBL188469 | — | — | 1 | - |
| CHEMBL363268 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111659 | ALTINICLINE | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL606669 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL187927 | DIANICLINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL134713 | GTS-21 | EC50 | > | 10000.0 | nM | - |
| CHEMBL189861 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL188469 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL363268 | — | EC50 | > | 10000.0 | nM | - |