Assay Detail
Functional
CHEMBL830036
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity against Nicotinic acetylcholine receptor alpha-7 - 5-hydroxytryptamine 3 receptor chimera
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.81 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177611 | PNU-282987 | — | 1 | 6.89 |
| CHEMBL554984 | — | — | 1 | 6.81 |
| CHEMBL362189 | — | — | 1 | 6.79 |
| CHEMBL360111 | — | — | 1 | 6.69 |
| CHEMBL179724 | — | — | 1 | 6.49 |
| CHEMBL178968 | — | — | 1 | 6.44 |
| CHEMBL178760 | — | — | 1 | 6.31 |
| CHEMBL369746 | — | — | 1 | 6.30 |
| CHEMBL178291 | — | — | 1 | 6.00 |
| CHEMBL179405 | — | — | 1 | 5.82 |
| CHEMBL41294 | — | — | 1 | 5.72 |
| CHEMBL179362 | — | — | 1 | 5.66 |
| CHEMBL178894 | — | — | 1 | 5.48 |
| CHEMBL435719 | — | — | 1 | 5.42 |
| CHEMBL180115 | — | — | 1 | 4.78 |
| CHEMBL360024 | — | — | 1 | 4.52 |
| CHEMBL362279 | — | — | 1 | 4.52 |
| CHEMBL179068 | — | — | 1 | 4.00 |
| CHEMBL178709 | — | — | 1 | - |
| CHEMBL361393 | — | — | 1 | - |
| CHEMBL360994 | — | — | 1 | - |
| CHEMBL178811 | — | — | 1 | - |
| CHEMBL290132 | — | — | 1 | - |
| CHEMBL360797 | — | — | 1 | - |
| CHEMBL179010 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177611 | PNU-282987 | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL554984 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL362189 | — | EC50 | = | 164.0 | nM | 6.79 |
| CHEMBL360111 | — | EC50 | = | 206.0 | nM | 6.69 |
| CHEMBL179724 | — | EC50 | = | 324.0 | nM | 6.49 |
| CHEMBL178968 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL178760 | — | EC50 | = | 494.0 | nM | 6.31 |
| CHEMBL369746 | — | EC50 | = | 506.0 | nM | 6.30 |
| CHEMBL178291 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL179405 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL41294 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL179362 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL178894 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL435719 | — | EC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL180115 | — | EC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL360024 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL362279 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL179068 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL178709 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL361393 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL360994 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL178811 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL290132 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL360797 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL179010 | — | EC50 | > | 100000.0 | nM | - |