Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL830063

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro binding affinity for PPAR-alpha
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.
Shi GQ, Dropinski JF, Zhang Y, Santini C, Sahoo SP, Berger JP, Macnaul KL, Zhou G, Agrawal A, Alvaro R, Cai TQ, Hernandez M, Wright SD, Moller DE, Heck JV, Meinke PT.
J Med Chem (2005) 48 : 5589 -5599
PubMed 16107159 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 7.33 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL425725 1 8.52
CHEMBL366145 1 8.52
CHEMBL189110 1 8.40
CHEMBL190334 1 8.40
CHEMBL190603 1 8.22
CHEMBL363780 1 8.15
CHEMBL192609 1 8.05
CHEMBL192500 1 7.96
CHEMBL190968 1 7.77
CHEMBL190976 1 7.68
CHEMBL370024 1 7.66
CHEMBL192638 1 7.50
CHEMBL189844 1 7.38
CHEMBL192582 1 6.97
CHEMBL426269 1 6.79
CHEMBL193459 1 6.64
CHEMBL363006 1 6.58
CHEMBL192774 1 6.56
CHEMBL363154 1 6.11
CHEMBL192791 1 5.89
CHEMBL191489 1 5.86
CHEMBL192291 1 5.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL425725 IC50 = 3.0 nM 8.52
CHEMBL366145 IC50 = 3.0 nM 8.52
CHEMBL189110 IC50 = 4.0 nM 8.40
CHEMBL190334 IC50 = 4.0 nM 8.40
CHEMBL190603 IC50 = 6.0 nM 8.22
CHEMBL363780 IC50 = 7.0 nM 8.15
CHEMBL192609 IC50 = 9.0 nM 8.05
CHEMBL192500 IC50 = 11.0 nM 7.96
CHEMBL190968 IC50 = 17.0 nM 7.77
CHEMBL190976 IC50 = 21.0 nM 7.68
CHEMBL370024 IC50 = 22.0 nM 7.66
CHEMBL192638 IC50 = 32.0 nM 7.50
CHEMBL189844 IC50 = 42.0 nM 7.38
CHEMBL192582 IC50 = 106.0 nM 6.97
CHEMBL426269 IC50 = 162.0 nM 6.79
CHEMBL193459 IC50 = 231.0 nM 6.64
CHEMBL363006 IC50 = 264.0 nM 6.58
CHEMBL192774 IC50 = 275.0 nM 6.56
CHEMBL363154 IC50 = 786.0 nM 6.11
CHEMBL192791 IC50 = 1280.0 nM 5.89
CHEMBL191489 IC50 = 1390.0 nM 5.86
CHEMBL192291 IC50 = 2227.0 nM 5.65