Assay Detail
Binding
CHEMBL830064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity for PPAR-delta
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.92 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192609 | — | — | 1 | 6.40 |
| CHEMBL189844 | — | — | 1 | 6.08 |
| CHEMBL370024 | — | — | 1 | 5.92 |
| CHEMBL192500 | — | — | 1 | 5.28 |
| CHEMBL363154 | — | — | 1 | - |
| CHEMBL192638 | — | — | 1 | - |
| CHEMBL363780 | — | — | 1 | - |
| CHEMBL192774 | — | — | 1 | - |
| CHEMBL190603 | — | — | 1 | - |
| CHEMBL192291 | — | — | 1 | - |
| CHEMBL366145 | — | — | 1 | - |
| CHEMBL192791 | — | — | 1 | - |
| CHEMBL193459 | — | — | 1 | - |
| CHEMBL190968 | — | — | 1 | - |
| CHEMBL425725 | — | — | 1 | - |
| CHEMBL190334 | — | — | 1 | - |
| CHEMBL189110 | — | — | 1 | - |
| CHEMBL190976 | — | — | 1 | - |
| CHEMBL426269 | — | — | 1 | - |
| CHEMBL363006 | — | — | 1 | - |
| CHEMBL192582 | — | — | 1 | - |
| CHEMBL191489 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192609 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL189844 | — | IC50 | = | 834.0 | nM | 6.08 |
| CHEMBL370024 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL192500 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL363154 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL192638 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL363780 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL192774 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL190603 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL192291 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL366145 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL192791 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL193459 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL190968 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL425725 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL190334 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL189110 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL190976 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL426269 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL363006 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL192582 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL191489 | — | IC50 | > | 50000.0 | nM | - |