Assay Detail
Binding
CHEMBL830070
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 9.21 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186552 | — | — | 1 | 10.15 |
| CHEMBL187289 | — | — | 1 | 10.10 |
| CHEMBL186126 | — | — | 1 | 9.96 |
| CHEMBL189201 | — | — | 1 | 9.70 |
| CHEMBL425717 | — | — | 1 | 9.68 |
| CHEMBL361936 | — | — | 1 | 9.28 |
| CHEMBL180489 | — | — | 1 | 9.19 |
| CHEMBL188406 | — | — | 1 | 9.03 |
| CHEMBL150678 | — | — | 1 | 8.48 |
| CHEMBL183998 | — | — | 1 | 8.14 |
| CHEMBL83649 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186552 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL187289 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL186126 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL189201 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL425717 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL361936 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL180489 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL188406 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL150678 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL183998 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL83649 | — | IC50 | = | 22.7 | nM | 7.64 |