Assay Detail
Binding
CHEMBL830077
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Dissociation constant for nicotinic acetylcholine receptor alpha4-beta2 of mouse M10 cells; n=3
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | M10 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.69 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366923 | — | — | 1 | 9.41 |
| CHEMBL9732 | R-NICOTINE | — | 1 | 8.51 |
| CHEMBL6200 | NORNICOTINE | 1.0 | 1 | 8.51 |
| CHEMBL6623 | EPIBATIDINE | — | 1 | 8.51 |
| CHEMBL149667 | — | — | 1 | 8.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366923 | — | Kd | = | 0.39 | nM | 9.41 |
| CHEMBL9732 | R-NICOTINE | Kd | = | 3.08 | nM | 8.51 |
| CHEMBL6200 | NORNICOTINE | Kd | = | 3.08 | nM | 8.51 |
| CHEMBL6623 | EPIBATIDINE | Kd | = | 3.08 | nM | 8.51 |
| CHEMBL149667 | — | Kd | = | 3.08 | nM | 8.51 |