Assay Detail
Binding
CHEMBL830079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant for nicotinic acetylcholine receptor alpha 7 from human neuroblastoma SH-SY5Y cells; n=3
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.97 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9732 | R-NICOTINE | — | 1 | 8.97 |
| CHEMBL6200 | NORNICOTINE | 1.0 | 1 | 8.97 |
| CHEMBL6623 | EPIBATIDINE | — | 1 | 8.97 |
| CHEMBL149667 | — | — | 1 | 8.97 |
| CHEMBL366923 | — | — | 1 | 8.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9732 | R-NICOTINE | Kd | = | 1.06 | nM | 8.97 |
| CHEMBL6200 | NORNICOTINE | Kd | = | 1.06 | nM | 8.97 |
| CHEMBL6623 | EPIBATIDINE | Kd | = | 1.06 | nM | 8.97 |
| CHEMBL149667 | — | Kd | = | 1.06 | nM | 8.97 |
| CHEMBL366923 | — | Kd | = | 1.06 | nM | 8.97 |