Assay Detail
Binding
CHEMBL830081
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Inhibition constant against human (cloned) isozyme (hCA II) by CO2 hydration method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.47 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL361496 | — | — | 1 | 7.57 |
| CHEMBL360604 | — | — | 1 | 7.47 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL187947 | — | — | 1 | 7.40 |
| CHEMBL191109 | — | — | 1 | 7.39 |
| CHEMBL187919 | — | — | 1 | 7.37 |
| CHEMBL372888 | — | — | 1 | 7.36 |
| CHEMBL186522 | — | — | 1 | 7.35 |
| CHEMBL187974 | — | — | 1 | 7.33 |
| CHEMBL188750 | — | — | 1 | 7.30 |
| CHEMBL188002 | — | — | 1 | 7.28 |
| CHEMBL366082 | — | — | 1 | 7.28 |
| CHEMBL7087 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL361496 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL360604 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL187947 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL191109 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL187919 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL372888 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL186522 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL187974 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL188750 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL188002 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL366082 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL7087 | — | Ki | = | 160.0 | nM | 6.80 |