Assay Detail
Functional
CHEMBL830086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of [35S]GTPcS binding against recombinant human opioid receptor mu 1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.97 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362202 | DEPROTECTED COGENER OF M6G | — | 1 | 7.43 |
| CHEMBL1330 | MORPHINE GLUCURONIDE | 2.0 | 1 | 7.14 |
| CHEMBL359534 | — | — | 1 | 7.04 |
| CHEMBL359644 | — | — | 1 | 7.04 |
| CHEMBL366917 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362202 | DEPROTECTED COGENER OF M6G | EC50 | = | 37.2 | nM | 7.43 |
| CHEMBL1330 | MORPHINE GLUCURONIDE | EC50 | = | 72.3 | nM | 7.14 |
| CHEMBL359534 | — | EC50 | = | 90.6 | nM | 7.04 |
| CHEMBL359644 | — | EC50 | = | 91.5 | nM | 7.04 |
| CHEMBL366917 | — | EC50 | = | 622.6 | nM | 6.21 |