Assay Detail
Binding
CHEMBL830100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against Nicotinic acetylcholine receptor alpha 7 expressed in xenopus oocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Xenopus laevis |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.33 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134752 | DIMETHYLPHENYLPIPERAZINIUM | — | 1 | 4.51 |
| CHEMBL497939 | CYTISINICLINE | 3.0 | 1 | 4.15 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134752 | DIMETHYLPHENYLPIPERAZINIUM | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL497939 | CYTISINICLINE | EC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 180000.0 | nM | - |