Assay Detail
Functional
CHEMBL830106
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of [35S]GTPcS binding against recombinant human opioid receptor kappa 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.00 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366917 | — | — | 1 | 8.74 |
| CHEMBL359644 | — | — | 1 | 6.49 |
| CHEMBL362202 | DEPROTECTED COGENER OF M6G | — | 1 | 5.76 |
| CHEMBL1330 | MORPHINE GLUCURONIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366917 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL359644 | — | EC50 | = | 321.0 | nM | 6.49 |
| CHEMBL362202 | DEPROTECTED COGENER OF M6G | EC50 | = | 1717.5 | nM | 5.76 |
| CHEMBL1330 | MORPHINE GLUCURONIDE | EC50 | > | 10000.0 | nM | - |