Assay Detail
Binding
CHEMBL830112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Phosphodiesterase 5
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.54 | 4.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185296 | — | — | 1 | 4.94 |
| CHEMBL183465 | — | — | 1 | 4.53 |
| CHEMBL182703 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185296 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL183465 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL182703 | — | IC50 | = | 69800.0 | nM | 4.16 |