Assay Detail
Binding
CHEMBL830129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]nisoxetine binding to norepinephrine transporter expressed in human kidney cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | kidney |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.80 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190700 | — | — | 1 | 8.30 |
| CHEMBL2113055 | — | — | 1 | 7.43 |
| CHEMBL22183 | — | — | 1 | 7.21 |
| CHEMBL413562 | — | — | 1 | 6.97 |
| CHEMBL2113054 | — | — | 1 | 6.72 |
| CHEMBL187935 | — | — | 1 | 6.71 |
| CHEMBL363396 | — | — | 1 | 6.66 |
| CHEMBL190703 | — | — | 1 | 6.57 |
| CHEMBL190937 | — | — | 1 | 6.52 |
| CHEMBL189367 | — | — | 1 | 6.43 |
| CHEMBL189375 | — | — | 1 | 6.35 |
| CHEMBL362783 | — | — | 1 | 6.32 |
| CHEMBL23034 | — | — | 1 | 6.16 |
| CHEMBL188964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190700 | — | Ki | = | 4.95 | nM | 8.30 |
| CHEMBL2113055 | — | Ki | = | 37.52 | nM | 7.43 |
| CHEMBL22183 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL413562 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL2113054 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL187935 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL363396 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL190703 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL190937 | — | Ki | = | 303.0 | nM | 6.52 |
| CHEMBL189367 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL189375 | — | Ki | = | 445.36 | nM | 6.35 |
| CHEMBL362783 | — | Ki | = | 483.55 | nM | 6.32 |
| CHEMBL23034 | — | Ki | = | 699.0 | nM | 6.16 |
| CHEMBL188964 | — | Ki | > | 5000.0 | nM | - |