Assay Detail
Binding
CHEMBL830160
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Fibroblast growth factor receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Fibroblast growth factor receptor (CHEMBL2095217) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.50 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425876 | — | — | 1 | 7.52 |
| CHEMBL299763 | — | — | 1 | 7.22 |
| CHEMBL57366 | — | — | 1 | 6.89 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425876 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL299763 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL57366 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 43000.0 | nM | 4.37 |