Assay Detail
Binding
CHEMBL830161
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Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.86 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180475 | — | — | 1 | 6.89 |
| CHEMBL175786 | — | — | 1 | 6.55 |
| CHEMBL175644 | — | — | 1 | 4.15 |
| CHEMBL177623 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180475 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL175786 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL175644 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL177623 | — | IC50 | = | 129000.0 | nM | - |