Assay Detail
Binding
CHEMBL830234
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Melanocortin 1 receptor using [125I]NDP-MSH
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL3795) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ".
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.47 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180937 | — | — | 1 | 6.28 |
| CHEMBL339053 | — | — | 1 | 6.12 |
| CHEMBL263182 | — | — | 1 | 5.70 |
| CHEMBL365039 | — | — | 1 | 5.70 |
| CHEMBL362670 | — | — | 1 | 5.66 |
| CHEMBL405150 | — | — | 1 | 5.50 |
| CHEMBL361052 | — | — | 1 | 4.96 |
| CHEMBL185195 | — | — | 1 | 4.89 |
| CHEMBL362010 | — | — | 1 | 4.44 |
| CHEMBL363757 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180937 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL339053 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL263182 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL365039 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL362670 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL405150 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL361052 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL185195 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL362010 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL363757 | — | Ki | = | 152000.0 | nM | - |