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Assay Detail

CHEMBL830238

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards norepinephrine transporter determined using [3H]nisoxetine as radioligand
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters.
Carroll FI, Blough BE, Nie Z, Kuhar MJ, Howell LL, Navarro HA.
J Med Chem (2005) 48 : 2767 -2771
PubMed 15828814 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 7.70 8.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL371812 1 8.90
CHEMBL189974 1 8.88
CHEMBL364920 1 8.71
CHEMBL362986 1 8.55
CHEMBL191266 1 8.14
CHEMBL364665 1 7.98
CHEMBL192564 1 7.82
CHEMBL87031 1 7.75
CHEMBL127323 1 7.44
CHEMBL195159 1 7.39
CHEMBL193308 1 6.97
CHEMBL1790051 1 6.04
CHEMBL370805 COCAINE 4.0 1 5.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL371812 Ki = 1.26 nM 8.90
CHEMBL189974 Ki = 1.31 nM 8.88
CHEMBL364920 Ki = 1.96 nM 8.71
CHEMBL362986 Ki = 2.8 nM 8.55
CHEMBL191266 Ki = 7.24 nM 8.14
CHEMBL364665 Ki = 10.4 nM 7.98
CHEMBL192564 Ki = 15.1 nM 7.82
CHEMBL87031 Ki = 18.0 nM 7.75
CHEMBL127323 Ki = 36.2 nM 7.44
CHEMBL195159 Ki = 40.4 nM 7.39
CHEMBL193308 Ki = 107.0 nM 6.97
CHEMBL1790051 Ki = 920.0 nM 6.04
CHEMBL370805 COCAINE Ki = 3300.0 nM 5.48