Assay Detail
Binding
CHEMBL830239
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Inhibition of [125I]IABN binding to rat Dopamine D3 receptor expressed in HEK 293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.42 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300780 | — | — | 1 | 8.96 |
| CHEMBL71327 | — | — | 1 | 8.89 |
| CHEMBL71865 | — | — | 1 | 8.31 |
| CHEMBL304605 | — | — | 1 | 8.23 |
| CHEMBL69571 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300780 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL71327 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL71865 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL304605 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL69571 | — | Ki | = | 19.0 | nM | 7.72 |