Assay Detail
Binding
CHEMBL830275
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Inhibitory concentration against cruzain of Trypanosoma cruzi
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.17 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181504 | — | — | 1 | 7.72 |
| CHEMBL92099 | — | — | 1 | 7.52 |
| CHEMBL181752 | — | — | 1 | 7.52 |
| CHEMBL183396 | — | — | 1 | 7.52 |
| CHEMBL182790 | — | — | 1 | 7.52 |
| CHEMBL182795 | — | — | 1 | 7.40 |
| CHEMBL183005 | — | — | 1 | 7.40 |
| CHEMBL183767 | — | — | 1 | 7.10 |
| CHEMBL313679 | — | — | 1 | 6.51 |
| CHEMBL181902 | — | — | 1 | 5.52 |
| CHEMBL367811 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181504 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL92099 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL181752 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL183396 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL182790 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL182795 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL183005 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL183767 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL313679 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL181902 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL367811 | — | IC50 | > | 10000.0 | nM | - |