Assay Detail
Binding
CHEMBL830309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human immunodeficiency virus 1 protease
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.53 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 10.82 |
| CHEMBL195791 | — | — | 1 | 9.15 |
| CHEMBL191880 | — | — | 1 | 9.00 |
| CHEMBL426812 | — | — | 1 | 8.70 |
| CHEMBL195666 | — | — | 1 | 8.70 |
| CHEMBL364086 | — | — | 1 | 8.70 |
| CHEMBL192190 | — | — | 1 | 8.52 |
| CHEMBL372224 | — | — | 1 | 8.05 |
| CHEMBL194770 | — | — | 1 | 7.92 |
| CHEMBL191830 | — | — | 1 | 7.70 |
| CHEMBL372010 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL195791 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL191880 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL426812 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL195666 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL364086 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL192190 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL372224 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL194770 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL191830 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL372010 | — | Ki | = | 270.0 | nM | 6.57 |