Assay Detail
Binding
CHEMBL830361
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Binding affinity for matrix metalloprotease 13
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.98 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440498 | CTS-1027 | 2.0 | 1 | 9.28 |
| CHEMBL361527 | — | — | 2 | 9.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440498 | CTS-1027 | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL361527 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL361527 | — | Ki | = | 4.1 | nM | 8.39 |