Assay Detail
Binding
CHEMBL830381
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Binding affinity value against urokinase plasminogen activator
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.68 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182959 | — | — | 1 | 8.30 |
| CHEMBL362600 | — | — | 1 | 8.00 |
| CHEMBL182547 | — | — | 1 | 7.55 |
| CHEMBL181595 | — | — | 1 | 7.33 |
| CHEMBL185515 | — | — | 1 | 7.33 |
| CHEMBL182303 | — | — | 1 | 7.30 |
| CHEMBL183021 | — | — | 1 | 7.19 |
| CHEMBL319047 | — | — | 1 | 7.04 |
| CHEMBL179941 | — | — | 1 | 6.86 |
| CHEMBL182460 | — | — | 1 | 6.85 |
| CHEMBL360195 | — | — | 1 | 6.78 |
| CHEMBL104505 | — | — | 1 | 6.70 |
| CHEMBL183613 | — | — | 1 | 6.70 |
| CHEMBL182309 | — | — | 1 | 6.58 |
| CHEMBL182220 | — | — | 1 | 6.55 |
| CHEMBL362671 | — | — | 1 | 6.53 |
| CHEMBL182065 | — | — | 1 | 6.42 |
| CHEMBL181701 | — | — | 1 | 6.26 |
| CHEMBL181599 | — | — | 1 | 6.21 |
| CHEMBL184844 | — | — | 1 | 6.21 |
| CHEMBL104937 | — | — | 1 | 6.20 |
| CHEMBL182546 | — | — | 1 | 6.14 |
| CHEMBL360703 | — | — | 1 | 6.09 |
| CHEMBL185345 | — | — | 1 | 5.92 |
| CHEMBL426433 | — | — | 1 | 5.88 |
| CHEMBL182372 | — | — | 1 | 5.86 |
| CHEMBL184848 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182959 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL362600 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL182547 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL181595 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL185515 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL182303 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL183021 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL319047 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL179941 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL182460 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL360195 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL104505 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL183613 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL182309 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL182220 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL362671 | — | Ki | = | 293.0 | nM | 6.53 |
| CHEMBL182065 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL181701 | — | Ki | = | 548.0 | nM | 6.26 |
| CHEMBL181599 | — | Ki | = | 622.0 | nM | 6.21 |
| CHEMBL184844 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL104937 | — | Ki | = | 631.0 | nM | 6.20 |
| CHEMBL182546 | — | Ki | = | 731.0 | nM | 6.14 |
| CHEMBL360703 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL185345 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL426433 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL182372 | — | Ki | = | 1370.0 | nM | 5.86 |
| CHEMBL184848 | — | Ki | = | 3183.0 | nM | 5.50 |