Assay Detail
Binding
CHEMBL830403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for D2-like [3H]spiperone receptor was determined using caudate-putamen of adult male Spragueo?=Dawley rats
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Caudate-putamen |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.07 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25236 | BP-897 | — | 1 | 6.79 |
| CHEMBL426425 | — | — | 1 | 6.66 |
| CHEMBL341774 | — | — | 1 | 6.61 |
| CHEMBL362665 | — | — | 1 | 6.59 |
| CHEMBL359654 | — | — | 1 | 6.12 |
| CHEMBL179376 | — | — | 1 | 6.07 |
| CHEMBL181203 | — | — | 1 | 6.04 |
| CHEMBL179781 | — | — | 1 | 5.95 |
| CHEMBL179805 | — | — | 1 | 5.86 |
| CHEMBL179757 | — | — | 1 | 5.80 |
| CHEMBL180107 | — | — | 1 | 5.61 |
| CHEMBL345106 | — | — | 1 | 5.44 |
| CHEMBL413554 | — | — | 1 | 5.41 |
| CHEMBL368686 | — | — | 1 | - |
| CHEMBL361756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25236 | BP-897 | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL426425 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL341774 | — | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL362665 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL359654 | — | Ki | = | 762.0 | nM | 6.12 |
| CHEMBL179376 | — | Ki | = | 852.0 | nM | 6.07 |
| CHEMBL181203 | — | Ki | = | 906.0 | nM | 6.04 |
| CHEMBL179781 | — | Ki | = | 1125.0 | nM | 5.95 |
| CHEMBL179805 | — | Ki | = | 1389.0 | nM | 5.86 |
| CHEMBL179757 | — | Ki | = | 1568.0 | nM | 5.80 |
| CHEMBL180107 | — | Ki | = | 2443.0 | nM | 5.61 |
| CHEMBL345106 | — | Ki | = | 3643.0 | nM | 5.44 |
| CHEMBL413554 | — | Ki | = | 3887.0 | nM | 5.41 |
| CHEMBL368686 | — | Ki | > | 100.0 | nM | - |
| CHEMBL361756 | — | Ki | > | 250000.0 | nM | - |