Assay Detail
Binding
CHEMBL830429
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Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL2488) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of orally active prostaglandin D2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.39 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364593 | — | — | 1 | 7.22 |
| CHEMBL365829 | — | — | 1 | 7.05 |
| CHEMBL364841 | — | — | 1 | 7.00 |
| CHEMBL184684 | — | — | 1 | 6.60 |
| CHEMBL359564 | — | — | 1 | 6.55 |
| CHEMBL365243 | — | — | 1 | 6.48 |
| CHEMBL365696 | — | — | 1 | 6.39 |
| CHEMBL363984 | — | — | 1 | 6.35 |
| CHEMBL186735 | — | — | 1 | 6.27 |
| CHEMBL365908 | — | — | 1 | 5.89 |
| CHEMBL361457 | — | — | 1 | 5.89 |
| CHEMBL182555 | — | — | 1 | 5.70 |
| CHEMBL185251 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364593 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL365829 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL364841 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL184684 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL359564 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL365243 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL365696 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL363984 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL186735 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL365908 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL361457 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL182555 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL185251 | — | Ki | = | 2100.0 | nM | 5.68 |