Assay Detail
Binding
CHEMBL830878
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Inhibitory concentration against Vascular endothelial growth factor receptor 2
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.46 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359652 | — | — | 1 | 8.52 |
| CHEMBL369322 | — | — | 1 | 8.40 |
| CHEMBL360118 | — | — | 1 | 8.30 |
| CHEMBL178607 | — | — | 1 | 8.30 |
| CHEMBL178174 | — | — | 1 | 8.15 |
| CHEMBL178789 | — | — | 1 | 8.00 |
| CHEMBL360769 | — | — | 1 | 7.85 |
| CHEMBL179517 | — | — | 1 | 7.75 |
| CHEMBL180603 | — | — | 1 | 7.52 |
| CHEMBL360503 | — | — | 1 | 7.48 |
| CHEMBL178583 | — | — | 1 | 7.40 |
| CHEMBL180978 | — | — | 1 | 7.28 |
| CHEMBL178248 | — | — | 1 | 7.26 |
| CHEMBL181567 | — | — | 1 | 7.21 |
| CHEMBL178596 | — | — | 1 | 7.19 |
| CHEMBL360450 | — | — | 1 | 7.05 |
| CHEMBL180807 | — | — | 1 | 6.82 |
| CHEMBL181122 | — | — | 1 | 6.72 |
| CHEMBL181636 | — | — | 1 | 6.51 |
| CHEMBL178899 | — | — | 1 | 6.43 |
| CHEMBL359507 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359652 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL369322 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL360118 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL178607 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL178174 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL178789 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL360769 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL179517 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL180603 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL360503 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL178583 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL180978 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL178248 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL181567 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL178596 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL360450 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL180807 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL181122 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL181636 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL178899 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL359507 | — | IC50 | = | 380.0 | nM | 6.42 |