Assay Detail
Binding
CHEMBL830893
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Inhibitory concentration against beta-site APP cleaving enzyme (BACE-1) by fluorescence resonance energy transfer assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of cell-permeable non-peptide inhibitors of beta-secretase by high-throughput docking and continuum electrostatics calculations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.13 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370043 | — | — | 1 | 7.24 |
| CHEMBL190644 | — | — | 1 | 7.01 |
| CHEMBL190346 | — | — | 1 | - |
| CHEMBL363539 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370043 | — | IC50 | = | 57.8 | nM | 7.24 |
| CHEMBL190644 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL190346 | — | IC50 | > | 25.0 | nM | - |
| CHEMBL363539 | — | IC50 | = | 283900.0 | nM | - |