Assay Detail

CHEMBL830908

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of bovine farnesyl transferase in presence of Tipifarnib

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Bos taurus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.

Li Q, Li T, Woods KW, Gu WZ, Cohen J, Stoll VS, Galicia T, Hutchins C, Frost D, Rosenberg SH, Sham HL.
Bioorg Med Chem Lett (2005) 15 : 2918 -2922
PubMed 15911281 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.19	9.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL289228	TIPIFARNIB	3.0	1	9.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL289228	TIPIFARNIB	IC50	=	0.65	nM	9.19