Assay Detail
Functional
CHEMBL830912
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Inhibition of Hsp90 protein as degradation of HER2 kinase in SKBr3 cells
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SKBr3 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 4.74 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365159 | — | — | 1 | 6.52 |
| CHEMBL191635 | — | — | 1 | 6.09 |
| CHEMBL193282 | — | — | 1 | 5.89 |
| CHEMBL192145 | — | — | 1 | 5.84 |
| CHEMBL112953 | — | — | 1 | 5.82 |
| CHEMBL191786 | — | — | 1 | 5.66 |
| CHEMBL273986 | — | — | 1 | 5.50 |
| CHEMBL192062 | — | — | 1 | 5.46 |
| CHEMBL192647 | — | — | 1 | 5.04 |
| CHEMBL349231 | — | — | 1 | 4.98 |
| CHEMBL192937 | — | — | 1 | 4.91 |
| CHEMBL370247 | — | — | 1 | 4.86 |
| CHEMBL161992 | — | — | 1 | 4.83 |
| CHEMBL193259 | — | — | 1 | 4.68 |
| CHEMBL190518 | — | — | 1 | 4.65 |
| CHEMBL191268 | — | — | 1 | 4.64 |
| CHEMBL439852 | — | — | 1 | 4.63 |
| CHEMBL191920 | — | — | 1 | 4.58 |
| CHEMBL364450 | — | — | 1 | 4.58 |
| CHEMBL191241 | — | — | 1 | 4.55 |
| CHEMBL352683 | — | — | 1 | 4.54 |
| CHEMBL189537 | — | — | 1 | 4.50 |
| CHEMBL364456 | — | — | 1 | 4.45 |
| CHEMBL424824 | — | — | 1 | 4.41 |
| CHEMBL370092 | — | — | 1 | 4.36 |
| CHEMBL426086 | — | — | 1 | 4.35 |
| CHEMBL194716 | — | — | 1 | 4.32 |
| CHEMBL191601 | — | — | 1 | 4.32 |
| CHEMBL195869 | — | — | 1 | 4.27 |
| CHEMBL192649 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365159 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL191635 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL193282 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL192145 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL112953 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL191786 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL273986 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL192062 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL192647 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL349231 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL192937 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL370247 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL161992 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL193259 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL190518 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL191268 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL439852 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL191920 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL364450 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL191241 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL352683 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL189537 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL364456 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL424824 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL370092 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL426086 | — | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL191601 | — | IC50 | = | 47600.0 | nM | 4.32 |
| CHEMBL194716 | — | IC50 | = | 47800.0 | nM | 4.32 |
| CHEMBL195869 | — | IC50 | = | 53700.0 | nM | 4.27 |
| CHEMBL192649 | — | IC50 | = | 57200.0 | nM | 4.24 |
| CHEMBL192480 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL363196 | — | IC50 | = | 58300.0 | nM | 4.23 |
| CHEMBL192013 | — | IC50 | = | 60500.0 | nM | 4.22 |
| CHEMBL191668 | — | IC50 | = | 65300.0 | nM | 4.18 |
| CHEMBL193672 | — | IC50 | = | 70300.0 | nM | 4.15 |
| CHEMBL370286 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL191641 | — | IC50 | = | 88500.0 | nM | 4.05 |
| CHEMBL371372 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL193056 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL193313 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL193892 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL190438 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL193310 | — | IC50 | = | 105000.0 | nM | - |
| CHEMBL190439 | — | IC50 | = | 195000.0 | nM | - |
| CHEMBL190654 | — | IC50 | = | 315000.0 | nM | - |
| CHEMBL372013 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL362972 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL427169 | — | IC50 | = | 157000.0 | nM | - |
| CHEMBL192761 | — | IC50 | = | 110300.0 | nM | - |
| CHEMBL364272 | — | IC50 | = | 122000.0 | nM | - |