Assay Detail
Binding
CHEMBL830918
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR protein isolated from HeLa cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.35 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.60 |
| CHEMBL435507 | — | — | 1 | 5.32 |
| CHEMBL179242 | — | — | 1 | 5.28 |
| CHEMBL104468 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98350 | LY-294002 | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL435507 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL179242 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL104468 | — | IC50 | = | 6400.0 | nM | 5.19 |