Assay Detail
Binding
CHEMBL830959
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Inhibitory concentration against human platelet-derived 12-lipoxygenase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3687) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.97 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425336 | — | — | 1 | 5.97 |
| CHEMBL433557 | — | — | 1 | - |
| CHEMBL360042 | — | — | 1 | - |
| CHEMBL181409 | — | — | 1 | - |
| CHEMBL179335 | — | — | 1 | - |
| CHEMBL178613 | — | — | 1 | - |
| CHEMBL180769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425336 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL433557 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL360042 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL181409 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL179335 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL178613 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL180769 | — | IC50 | > | 10000.0 | nM | - |