Assay Detail
Binding
CHEMBL830979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of A disintegrin and metalloprotease domain 12 (ADAM12) binding in cell based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 12 (CHEMBL5030) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.68 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 8.23 |
| CHEMBL366034 | — | — | 1 | 7.78 |
| CHEMBL361087 | — | — | 1 | 7.61 |
| CHEMBL188414 | — | — | 1 | 7.39 |
| CHEMBL365261 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | IC50 | = | 5.93 | nM | 8.23 |
| CHEMBL366034 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL361087 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL188414 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL365261 | — | IC50 | = | 42.3 | nM | 7.37 |